Kapersky labs have a wonderful but terrifying status report on malware.

Wonderful, because it is a calm look at the current status, terrifying because of what is happening. Key points

1. The dividing line between spyware and other malware is gone. Spyware will use any entry point to get onto your box.
2. There is enough resale value in online game artifacts that there are many bits of malware targeting Korean and Russian MMORPGs. All they need is your login, which may be less secured than your banking details.
3. Although Email is no longer the primary attack vector, IM is up and running
4. We should all be grateful no new core Windows holes have appeared for a few months; anything that allows worms must be feared
5. Mobile phones: yep, bluetooth is a vulnerability. Really. There is stuff in the wild.

Locating and eliminating botnets would be a fantastic project. They are a threat to everyone.